large DNA payload
ExoVec™ can carry genetic material up to 36 kb, which is several times more than conventional viral vectors.
Our Technology
EXOVEC™ — ENGINEERING EXOSOMES FOR PRECISION GENETIC DELIVERY
ExoVec™ is a modular delivery platform built on three integrated components: the exosome, the therapeutic DNA cargo, and our proprietary loading proteins. Together, they form a system that is precise, scalable and designed to reach tissues that no other gene therapy vector can access.
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Exosome, the body’s natural carrier of biological material
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Large strand DNA cargo (up to 36 kb)
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Proprietary exosome loading proteins (ELPs) that stabilize, protect, and deliver DNA cargo to the cell nucleus while resisting inflammation
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KEY FEATURES OF EXOVEC™
Minimal Toxicity
Built from the body's own vesicles, ExoVec™ is designed to deliver its cargo with low-to-no toxicity and minimal immune response.
Superior Delivery
ExoVec™ penetrates deep into target tissues, evades immune detection, and can reach organs that other delivery systems cannot.
COMPETITIVE ADVANTAGES
| Feature | ExoVec™ | Viral vectors | LNP |
|---|---|---|---|
| DNA cargo capacity | 36 kb | 5–10 kb | 15 kb |
| Nuclear delivery | Strong | Moderate to strong | Poor |
| Tissue penetration | Strong | Moderate | Poor |
| Safety | Designed for low immunogenicity | Low (pre-existing immunity) | Moderate (cellular toxicity) |
| Repeat dosing | Potential (in validation) | No | Yes |
| Production costs | Low / scalable | High | Moderate |
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Proof of Concept Data
Superior delivery, including 3D mini-hearts
More data available upon request.
Transduction comparison in a 3D mini-heart
No transfection
LNP
Ad vector
ExoVec™
- DAPI
- Nuclei of the cells
- cTnT
- Cardiomyocytes vitality marker
- GFP
- Transduction
- Vimentin
- Endothelial cells